Overview of therapeutic vaccination approaches for cancer.

  title={Overview of therapeutic vaccination approaches for cancer.},
  author={Neil L. Berinstein},
  journal={Seminars in oncology},
  volume={30 3 Suppl 8},
Recently, immunotherapy has been widely investigated for the treatment of cancer. While much of the success in this area lies with passive immunotherapy, the focus of this review is active vaccination strategies, which are showing promise. Cancer cells express a wide profile of different proteins, some of which are related to oncogenic transformation and are specific to cancer cells only. However, in cancer, most protein targets presented to the immune system from tumor cells are self-antigens… CONTINUE READING