Corpus ID: 8500390

Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.

@article{Majewski2016OverviewOT,
  title={Overview of the role of vitamins and minerals on the kynurenine pathway in health and disease.},
  author={Michael S. Majewski and Anna Karolina Kozłowska and Michael Thoene and Ewa Lepiarczyk and Waldemar Grzegorzewski},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2016},
  volume={67 1},
  pages={
          3-19
        }
}
The kynurenine pathway (KP) of L-tryptophan metabolism produces several neuroactive metabolites with an amino acid structure. These metabolites may play an important role in the pathophysiology of irritable bowel syndrome, Alzheimer's disease, Parkinson's disease, Huntington's disease, schizophrenia, AIDS-dementia complex, depression, epilepsy and the aging process. Modulation of the KP through inhibition or stimulation of enzyme synthesis and activity can be an alternative approach to… Expand
Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic Considerations
  • Ather Muneer
  • Medicine
  • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
  • 2020
TLDR
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TLDR
The present review gathers autonomic disturbances, the impaired kynurenine pathway in schizophrenia, and the effects of kynurenic acid pathway on autonomic functions and the possible therapeutic options are discussed. Expand
The kynurenine pathway in major depression: What we know and where to next
TLDR
The literature examining elements of the kynurenine pathway in depression is brought together and the implications for the pathophysiology and treatment of depression are explored, while highlighting the gaps in the current knowledge are highlighted. Expand
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References

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Kynurenine Pathway Metabolites in Humans: Disease and Healthy States
TLDR
This review compiles most of the studies and provides an overview of how the kynurenine pathway might be contributing to disease development, and the concentrations of tryptophan and kynuranines in the serum, cerebrospinal fluid and brain tissues in control and patient subjects. Expand
Changing the Face of Kynurenines and Neurotoxicity: Therapeutic Considerations
TLDR
Emerging knowledge about the kynurenine pathway provides new target points for the development of therapeutical solutions against neurodegenerative diseases. Expand
Kynurenines with Neuroactive and Redox Properties: Relevance to Aging and Brain Diseases
TLDR
Each kynurenine is described remarking their redox properties, their effects in experimental models, their alterations in the aging process, and their roles in bioenergetic and biosynthetic metabolism. Expand
Kynurenine metabolism in Alzheimer's disease
TLDR
The present data indicate an elevated kynurenine metabolism in AD brain and a marked increase of KYNA in the caudate nucleus and putamen may compensate the hyperactivity of the striato-frontal loop in AD brains. Expand
Structural basis of kynurenine 3-monooxygenase inhibition
TLDR
The first crystal structure of Saccharomyces cerevisiae KMO is reported, in the free form and in complex with the tight-binding inhibitor UPF’s648, validating the yeast KMO–UPF 648 structure as a template for structure-based drug design. Expand
Insulin Resistance and Dysregulation of Tryptophan–Kynurenine and Kynurenine–Nicotinamide Adenine Dinucleotide Metabolic Pathways
TLDR
It is proposed that one of the mechanisms of IR is inflammation- and/or stress-induced upregulation of TRP–KYN metabolism in combination with P5P deficiency-induced diversion of KYN–NAD metabolism towards formation of XA and other KYN derivatives affecting insulin activity. Expand
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TLDR
It is concluded that inflammatory diseases are associated with accumulation of QUIN, kynurenic acid and L-kynurenine within the central nervous system, but that the available data do not support a role for QUIN in the aetiology of Huntington's disease or Alzheimer's disease. Expand
Increased 3-Hydroxykynurenine serum concentrations differentiate Alzheimer’s disease patients from controls
TLDR
The data indicate an increased production of the neurotoxic KP metabolite 3-HK in AD, which can cross the blood–brain barrier via an active transport process and may be related to the previously reported higher production of QUIN in AD brains. Expand
Response of kynurenine pathway enzymes to pregnancy and dietary level of vitamin B-6
TLDR
Data show that pregnancy has a more pronounced effect on KYNase activity than vitamin B-6 restriction, and that the effects of pregnancy and diet are additive, and the alteration in the kynurenine pathway in pregnancy is due to a reduction in KYNases activity, which is resistant to alleviation by vitamin B -6 supplementation. Expand
Tryptophan kynurenine metabolism as a common mediator of genetic and environmental impacts in major depressive disorder: the serotonin hypothesis revisited 40 years later.
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  • Medicine
  • The Israel journal of psychiatry and related sciences
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TLDR
The present review of genetic and hormonal factors regulating kynurenine pathway of tryptophan metabolism suggests that this pathway mediates both genetic and environmental mechanisms of depression. Expand
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