Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action.

@article{Mersmann1998OverviewOT,
  title={Overview of the effects of beta-adrenergic receptor agonists on animal growth including mechanisms of action.},
  author={Harry John Mersmann},
  journal={Journal of animal science},
  year={1998},
  volume={76 1},
  pages={
          160-72
        }
}
  • H. Mersmann
  • Published 1998
  • Biology
  • Journal of animal science
The beta-adrenergic receptors (beta-AR) are present on the surface of almost every type of mammalian cell. These receptors are stimulated physiologically by the neurotransmitter, norepinephrine and the adrenal medullary hormone, epinephrine. There are three subtypes of beta-AR, namely, beta1-AR, beta2-AR, and beta3-AR; the pharmacological and physiological responses of an individual cell result from the particular mixture of the three beta-AR subtypes present on that cell. Species-specific… 

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References

SHOWING 1-10 OF 79 REFERENCES

[Biotechnology of beta-adrenergic receptors].

Results of studies of beta-adrenergic receptors suggest that some amino acids in the seven membrane-spanning domains are part of the ligand-binding site, whereas the protein G-coupling site seems to involve amino acids located in the third cytoplasmic loop and in the C-terminal extremity, which also contains the phosphorylation sites.

Species variation in mechanisms for modulation of growth by beta-adrenergic receptors.

There is good evidence for the inhibition of adipose tissue lipogenesis and stimulation of lipolysis as well as stimulation of skeletal muscle protein synthesis and inhibition of degradation in beta-adrenergic agonists fed to avian and mammalian species.

Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function.

The cloning of .B2AR cDNA from hamster, human, rat, and mouse, as well as the gene from human genomic DNA, has allowed us to study the signal transduction pathway initiated by the f32AR and mediated by Gs.

Pharmacological characteristics and species‐related variations of β3‐adrenergic receptors

This review discusses the structure and function of β3‐AR in various species and presents new findings on a number of β2‐AR ligands including carazolol, tertatolol and CL 316,243 which were found to be selective and potent β3-AR agonists and ZD 2079 and salmeterol which appear to display full but non‐subtype selective agonistic activity.

Quantitative characterization of beta-adrenergic receptor subtypes in porcine adipocytes.

β-adrenergic agonists and hypertrophy of skeletal muscles

Species and strain-related differences in the expression and functionality of beta-adrenoceptor subtypes in adipose tissue.

It is concluded that the presence and the physiological relevance of beta-adrenoceptor subtypes in adipose tissue may not only be species-related, but also strain-related.
...