Overview of the cellular and molecular basis of kidney fibrosis

  title={Overview of the cellular and molecular basis of kidney fibrosis},
  author={Allison A. Eddy},
  booktitle={Kidney international supplements},
The common pathogenetic pathway of progressive injury in patients with chronic kidney disease (CKD) is epitomized as normal kidney parenchymal destruction due to scarring (fibrosis). Understanding the fundamental pathways that lead to renal fibrosis is essential in order to develop better therapeutic options for human CKD. Although complex, four cellular responses are pivotal. (1) An interstitial inflammatory response that has multiple consequences-some harmful and others healing. (2) The… CONTINUE READING
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