Overview of the biology of type I interferons

  title={Overview of the biology of type I interferons},
  author={George D Kalliolias and Lionel B Ivashkiv},
  booktitle={Arthritis research & therapy},
Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be anti-inflammatory and tissue protective or can be proinflammatory and promote autoimmunity. Along these lines, the activation of type I interferon pathways is effective in suppressing disease activity in patients with multiple sclerosis and in animal models of arthritis and colitis, while… CONTINUE READING