• DOI:10.2165/00003088-199500291-00003
Corpus ID: 71812133

Overview of the Pharmacokinetics of Fluvoxamine

@article{Harten1995OverviewOT,
  title={Overview of the Pharmacokinetics of Fluvoxamine},
  author={Jaap van Harten},
  journal={Clinical Pharmacokinetics},
  year={1995},
  volume={29},
  pages={1-9}
}

Jaap van Harten

Published 1995

Medicine

Clinical Pharmacokinetics

SummaryThe pharmacokinetics of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) with antidepressant properties, are well established. After oral administration, the drug is almost completely absorbed from the gastrointestinal tract, and the extent of absorption is unaffected by the presence of food. Despite complete absorption, oral bioavailability in man is ≈ 50% on account of first-pass hepatic metabolism. Peak plasma fluvoxamine concentrations are reached 4 to 12 hours (enteric… CONTINUE READING

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