Overview of the Pharmacokinetics of Fluvoxamine

@article{Harten1995OverviewOT,
  title={Overview of the Pharmacokinetics of Fluvoxamine},
  author={Jaap van Harten},
  journal={Clinical Pharmacokinetics},
  year={1995},
  volume={29},
  pages={1-9}
}
  • J. Harten
  • Published 1995
  • Medicine, Biology
  • Clinical Pharmacokinetics
SummaryThe pharmacokinetics of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) with antidepressant properties, are well established. After oral administration, the drug is almost completely absorbed from the gastrointestinal tract, and the extent of absorption is unaffected by the presence of food. Despite complete absorption, oral bioavailability in man is ≈ 50% on account of first-pass hepatic metabolism. Peak plasma fluvoxamine concentrations are reached 4 to 12 hours (enteric… 
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References

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Fluvoxamine pharmacokinetics are substantially unaltered in the elderly, whereas higher plasma drug concentrations (relative to dose) are observed in patients with alcoholic cirrhosis of the liver, and preliminary data suggest that plasmaDrug concentrations may increase non-linearly with increasing daily dosage.
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Fluvoxamine inhibits the biotransformation of diazepam and its active N‐demethylated metabolite, and the magnitude of this interaction is likely to have considerable clinical significance.
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TLDR
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