Overview of the Pharmacokinetics of Fluvoxamine

@article{Harten1995OverviewOT,
  title={Overview of the Pharmacokinetics of Fluvoxamine},
  author={J. Harten},
  journal={Clinical Pharmacokinetics},
  year={1995},
  volume={29},
  pages={1-9}
}
  • J. Harten
  • Published 1995
  • Medicine
  • Clinical Pharmacokinetics
SummaryThe pharmacokinetics of fluvoxamine, a selective serotonin reuptake inhibitor (SSRI) with antidepressant properties, are well established. After oral administration, the drug is almost completely absorbed from the gastrointestinal tract, and the extent of absorption is unaffected by the presence of food. Despite complete absorption, oral bioavailability in man is ≈ 50% on account of first-pass hepatic metabolism. Peak plasma fluvoxamine concentrations are reached 4 to 12 hours (enteric… Expand
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