Overview of synergy with reference to double beta-lactam combinations.

  title={Overview of synergy with reference to double beta-lactam combinations.},
  author={Alan W. Hopefl},
  journal={DICP : the annals of pharmacotherapy},
  volume={25 9},
Combination antimicrobial therapy is used to expand the bacterial coverage over a single agent, to prevent the emergence of resistant organisms, to decrease toxicity by allowing lower doses of both agents, or for synergy. Synergy is one of the most common of these reasons, especially in serious infections. The introduction of new broad-spectrum beta-lactam antimicrobials has led to their combination in the treatment of seriously ill patients. Whereas a combination of an aminoglycoside and a… CONTINUE READING