Overview of studies of treatments for hand eczema—the EDEN hand eczema survey

@article{vanCoevorden2004OverviewOS,
  title={Overview of studies of treatments for hand eczema—the EDEN hand eczema survey},
  author={A Marco van Coevorden and Pieter Jan Coenraads and {\AA}ke Svensson and Jan Nico Bouwes Bavinck and Thomas L. Diepgen and Luigi Naldi and Peter Elsner and H C Williams},
  journal={British Journal of Dermatology},
  year={2004},
  volume={151}
}
Background  Hand eczema is a major cause of morbidity and lost earnings. Many interventions ranging from topical steroids to oral ciclosporin are used, but their evidence base and the best methods to assess their efficacy are uncertain. 
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References

SHOWING 1-10 OF 17 REFERENCES
Long‐term, intermittent treatment of chronic hand eczema with mometasone furoate
TLDR
It is concluded that long‐term, intermittent treatment of chronic hand eczema with mometasone furoate fatty cream is effective and safe. Expand
Comparison of cyclosporine and topical betamethasone-17,21-dipropionate in the treatment of severe chronic hand eczema.
TLDR
Low-dose cyclosporine at 3 mg/kg/day is as effective as topical BDP in the treatment of chronic hand Eczema and could be useful as an alternative treatment for severe chronic hand eczema in patients unresponsive to conventional treatment. Expand
Treatment of hyperkeratotic dermatitis of the palms (eczema keratoticum) with oral acitretin. A single-blind placebo-controlled study.
TLDR
It is concluded that 30 mg of acitretin is efficacious and safe to use in patients with hyperkeratotic dermatitis of the palms, and after 4 weeks of treatment, a 51% reduction of all symptoms was observed among patients receiving ac itretin. Expand
Hand eczema in Swedish adults - changes in prevalence between 1983 and 1996.
TLDR
The study indicates that the prevalence of hand eczema in Swedish adults had decreased between 1983 and 1996 despite an increasing prevalence of childhood Eczema, and a decreased occupational exposure to skin irritants is a probable cause. Expand
Evaluating the outcome of treatment. Shouldn't We be asking patients if they are better?
  • J. Wright
  • Medicine
  • Journal of clinical epidemiology
  • 2000
TLDR
Patient-specific outcomes would provide a standardized method useful in research and clinical practice of asking patients whether they are better, and allow patients to state their individual concerns, and weight their relative importance. Expand
British Association of Dermatologists
TLDR
The British Association of Dermatologists guidelines for biologic therapy for psoriasis 2017 included guidelines for transition to/between biologic therapies, as well as advice on how to identify and assess patients at risk of falling foul of these guidelines. Expand
Assessing the quality of controlled clinical trials
TLDR
The concept of study quality and the methods used to assess quality are discussed and the methodology for both the assessment of quality and its incorporation into systematic reviews and meta-analysis is discussed. Expand
Quality of reporting of randomized trials as a measure of methodologic quality.
TLDR
Similar quality of reporting may hide important differences in methodologic quality, and well-conducted trials may be reported badly, so a clear distinction should be made between these 2 dimensions of the quality of RCTs. Expand
Improving the quality of reporting of randomized controlled trials. The CONSORT statement.
TLDR
For RCTs to ultimately benefit patients, the published report should be of the highest possible standard and accurate and complete reporting is needed. Expand
The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials
TLDR
The revised CONSORT statement is intended to improve the reporting of an RCT, enabling readers to understand a trial's conduct and to assess the validity of its results. Expand
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