Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution.

@article{Vega2005OverviewOS,
  title={Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution.},
  author={Ricardo C Rodr{\'i}guez de la Vega and Lourival Domingos Possani},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={2005},
  volume={46 8},
  pages={831-44}
}
Scorpion venoms contain a large number of bioactive components. Several of the long-chain peptides were shown to be responsible for neurotoxic effects, due to their ability to recognize Na(+) channels and to cause impairment of channel functions. Here, we revisited the basic paradigms in the study of these peptides in the light of recent data concerning their structure-function relationships, their functional divergence and extant biodiversity. The reviewed topics include: the criteria for… CONTINUE READING