Overview of rodent models for obesity research.


Animal obesity models differ widely in type and extent of obesity. They are either based on environmental factors (e.g., high-fat diet-induced obesity), spontaneous mutants (i.e., ob/ob mice), genetically engineered animals (e.g., mice with melanocortin receptor subtype-4 gene disruption (knock-out), or mechanical intervention (e.g., chemical lesion of the ventromedial hypothalamus). This unit reviews available rodent models to study obesity and attempts to highlight the greatest utility for each model.

DOI: 10.1002/0471142301.ns0910s17
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@article{Tschp2002OverviewOR, title={Overview of rodent models for obesity research.}, author={Matthias H Tsch{\"{o}p and Mark L. Heiman}, journal={Current protocols in neuroscience}, year={2002}, volume={Chapter 9}, pages={Unit 9.10} }