Overview of pathogenesis of systemic sclerosis.

@article{Abraham2009OverviewOP,
  title={Overview of pathogenesis of systemic sclerosis.},
  author={David J. Abraham and Thomas Krieg and Juergen Distler and Oliver Distler},
  journal={Rheumatology},
  year={2009},
  volume={48 Suppl 3},
  pages={iii3-7}
}
The aetiology of SSc is subject to ongoing research, as the precise events that underlie the development of this disease remain unclear. The pathogenesis is known to involve endothelium, epithelium, fibroblasts, innate and adaptive immune systems and their component immunological mediators. Endothelial cell damage may be the initiating factor, but the precise triggering event(s) remain elusive. Angiogenesis also appears to be dysregulated. Vasculopathy shows similarities in different organs (e… CONTINUE READING
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factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum 2007;56:334–44

  • DJ Abraham, B Eckes, V Rajkumar, T. Krieg
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