Overview of human cytomegalovirus pathogenesis.

@article{Nogalski2014OverviewOH,
  title={Overview of human cytomegalovirus pathogenesis.},
  author={Maciej T. Nogalski and Donna Collins-McMillen and Andrew D. Yurochko},
  journal={Methods in molecular biology},
  year={2014},
  volume={1119},
  pages={
          15-28
        }
}
Human cytomegalovirus (HCMV) is a human pathogen that infects greater than 50 % of the human population. HCMV infection is usually asymptomatic in most individuals. That is, primary infection or reactivation of latent virus is generally clinically silent. HCMV infection, however, is associated with significant morbidity and mortality in the immunocompromised and chronic inflammatory diseases in the immunocompetent. In immunocompromised individuals (acquired immune deficiency syndrome and… 
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CMV reactivation occurs in patients with rheumatologic disease, can result in severe clinical sequelae, and is difficult to distinguish from a flare of the underlying disease.
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TLDR
The complex persistence of HCMV is reviewed with consideration of latent reservoirs, viral determinants and their host interactions, and host signaling and the control of cellular and viral gene expression that contributes to the establishment of and reactivation from latency.
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TLDR
The induction of a uniquely polarized macrophage subset from infected monocytes is described, which is argued to be the ideal cellular environment for the initiation of viral gene expression and replication and, ultimately, viral spread and persistence within the infected host.
The Role of Human Cytomegalovirus Infection in Glioblastoma Multiforme Pathogenesis: Review of the Literature
TLDR
Previous researches have shown the presence of Human Cytomegalovirus nucleic acids and Proteins in GBM tumor tissue, suggesting that the virus may implicate in its pathogenesis, by affecting tumor stem cell factors, angiogenesis and immune pathways, but this association remains controversial.
Case report: severe cytomegalovirus primary infection in an immunocompetent adult with disseminated intravascular coagulation treated with valganciclovir
TLDR
The first case of an immunocompetent patient suffering from DIC due to a CMV primary infection successfully treated with Valganciclovir is described, which indicates specific neutralisation capacity might need several weeks to develop.
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