Overview of hepatitis B viral replication and genetic variability.

@article{Tong2016OverviewOH,
  title={Overview of hepatitis B viral replication and genetic variability.},
  author={Shuping Tong and Peter A. Revill},
  journal={Journal of hepatology},
  year={2016},
  volume={64 1 Suppl},
  pages={S4-S16}
}
Chronic infection with hepatitis B virus (HBV) greatly increases the risk for liver cirrhosis and hepatocellular carcinoma (HCC). HBV isolates worldwide can be divided into ten genotypes. Moreover, the immune clearance phase selects for mutations in different parts of the viral genome. The outcome of HBV infection is shaped by the complex interplay of the mode of transmission, host genetic factors, viral genotype and adaptive mutations, as well as environmental factors. Core promoter mutations… CONTINUE READING
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