Overview of Serological-Specific IgE Antibody Testing in Children

@article{Cox2011OverviewOS,
  title={Overview of Serological-Specific IgE Antibody Testing in Children},
  author={Linda S. Cox},
  journal={Current Allergy and Asthma Reports},
  year={2011},
  volume={11},
  pages={447-453}
}
  • L. Cox
  • Published 23 September 2011
  • Biology, Medicine
  • Current Allergy and Asthma Reports
Allergic diseases are among the most common chronic conditions in the pediatric population. Allergy diagnostic testing is an important part of the evaluation/management of allergic patients because the history may not be precise enough to identify the specific allergen sensitivity. In addition to providing information about specific sensitivities, allergy diagnostic tests have some predictive value in terms of future risk of developing an allergic condition and the severity/persistence of the… 
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References

SHOWING 1-10 OF 46 REFERENCES
Proficiency survey-based evaluation of clinical total and allergen-specific IgE assay performance.
  • R. Hamilton
  • Medicine, Biology
    Archives of pathology & laboratory medicine
  • 2010
TLDR
Clinical total and allergen-specific IgE assays display excellent analytic sensitivity, precision, reproducibility, and linearity, which is a concern that may be ameliorated with componentAllergen use.
Skin test results but not serology reflect immediate type respiratory sensitivity: a study performed with recombinant allergen molecules.
TLDR
It is demonstrated on a molecular level that skin testing provides a better reflection of immediate type respiratory sensitivity than serology in vivo sensitivity with antibody-binding capacity in pollen allergic patients and eight control individuals.
Correlation of serum allergy (IgE) tests performed by different assay systems.
Molecular diagnosis in allergy
  • J. Sastre
  • Biology, Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2010
TLDR
This review provides a brief overview of basic information on allergen components, recombinants or purified, currently available or soon to become commercially available in ImmunoCAP or ISAC® systems, including names, protein family and function.
Diagnosing peanut allergy with skin prick and specific IgE testing.
Diagnosis of Food Allergy: Epicutaneous Skin Tests, In Vitro Tests, and Oral Food Challenge
TLDR
The usefulness and pitfalls of SPT and serum food-specific IgE levels are examined, as well as atopy patch testing and other emerging tests, such as component-resolved diagnostics and the basophil activation test are examined.
Utility of food-specific IgE concentrations in predicting symptomatic food allergy.
  • H. Sampson
  • Medicine
    The Journal of allergy and clinical immunology
  • 2001
TLDR
Quantification of food-specific IgE is a useful test for diagnosing symptomatic allergy to egg, milk, peanut, and fish in the pediatric population and could eliminate the need to perform double-blind, placebo-controlled food challenges in a significant number of children.
Efficacy of a single diagnostic test for sensitization to common inhalant allergens.
  • P. Williams, C. Siegel, J. Portnoy
  • Medicine
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology
  • 2001
...
1
2
3
4
5
...