Overview of HIV

@article{Klimas2008OverviewOH,
  title={Overview of HIV},
  author={Nancy Klimas and Anne O'Brien Koneru and Mary Ann Fletcher},
  journal={Psychosomatic Medicine},
  year={2008},
  volume={70},
  pages={523-530}
}
This article provides an overview and reviews the HIV pandemic, the basic biology and immunology of the virus (e.g., genetic diversity of HIV and the viral life cycle), the phases of disease progression, modes of HIV transmission, HIV testing, immune response to the infection, and current therapeutic strategies. HIV is occurring in epidemic proportions, especially in Sub-Saharan Africa. In the US, men who have sex with men account for over half of AIDS diagnoses; racial and ethnic minorities… Expand
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References

SHOWING 1-10 OF 77 REFERENCES
Hepatitis C and progression of HIV disease.
TLDR
Among patients in this urban US cohort, there was no evidence that HCV infection substantially alters the risk of dying, developing AIDS, or responding immunologically to HAART, especially after accounting for differences in its administration and effectiveness. Expand
HIV genetic diversity: biological and public health consequences.
TLDR
The distribution of these divergent viral forms worldwide and the potential consequences of such a tremendous viral diversity for diagnostic, monitoring, treatment and the development of an effective vaccine are discussed. Expand
Human immunodeficiency virus type 1 pharmacogenomics in clinical practice: relevance of HIV-1 drug resistance testing (Part 2).
  • R. Patarca, Alejandro Isava, +18 authors M. Fletcher
  • Biology, Medicine
  • Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • 2003
TLDR
This report summarizes studies published to date on the significance of testing of HIV-1 resistance to antiretroviral drugs and no published clinical trial results on the usefulness of the so-called virtual phenotype over genotypic sequencing alone are published. Expand
Human immunodeficiency virus type 1 pharmacogenomics in clinical practice: relevance of HIV-1 drug resistance testing (Part 1).
  • R. Patarca, Alejandro Isava, +18 authors M. Fletcher
  • Medicine
  • Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
  • 2003
TLDR
This report summarizes studies published to date on the significance of testing of HIV-1 resistance to antiretroviral drugs and no published clinical trials results on the usefulness of the so-called virtual phenotype over genotypic sequencing alone are published. Expand
Impact of hepatitis C on HIV progression in adults with alcohol problems.
TLDR
Hepatitis C virus infection has an adverse effect on CD4 cell count in patients with alcohol problems who are adherent to ART, and addressing HCV coinfection among these patients may confer additional immunologic benefit for this patient population. Expand
Gastrointestinal complications of HIV infection: changing priorities in the HAART era
TLDR
It has now been some 25 years since the initial description of AIDS and intense investigation has better characterised HIV, resulting in the development of effective drug therapies to arrest disease progression and, especially in the developing world, the cost and complexities of these regimens. Expand
HIV Pathogenesis: Knowledge Gained after Two Decades of Research
  • J. Levy
  • Biology, Medicine
  • Advances in dental research
  • 2006
TLDR
More details are needed about HIV's infection cycle and its pathologic effects in the body, as well as adaptive and innate immune activities mediating this anti-HIV effect. Expand
Should resistance testing be performed for treatment-naive HIV-infected patients? A cost-effectiveness analysis.
  • P. Sax, Runa Islam, +5 authors K. Freedberg
  • Medicine
  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
Genotype-resistance testing of chronically HIV-infected, antiretroviral-naive patients is likely to improve clinical outcomes and is cost-effective, compared with other HIV care in the United States. Expand
Disease progression, adherence, and response to protease inhibitor therapy for HIV infection in an Urban Veterans Affairs Medical Center.
TLDR
A review of the Miami cohort was conducted to evaluate response to indinavir plus two nucleoside analogues, and nonadherence to the regimen resulted in lost therapeutic benefit and suggested that strategies to enhance adherence may become an essential component of treatment. Expand
The role of the thymus in HIV infection: a 10 year perspective
TLDR
The data published during the last 10 years show that a possible increase in thymic output has an instrumental role in the immunopathogenesis that takes place during the clinically asymptomatic phase of HIV-1 infection. Expand
...
1
2
3
4
5
...