Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major

@inproceedings{PassosSilva2010OverviewOD,
  title={Overview of DNA Repair in Trypanosoma cruzi, Trypanosoma brucei, and Leishmania major},
  author={Danielle Gomes Passos-Silva and Matheus Andrade Raj{\~a}o and Pedro Henrique Nascimento de Aguiar and Jo{\~a}o Pedro Vieira-da-Rocha and Carlos Renato Machado and Carolina Furtado},
  booktitle={Journal of nucleic acids},
  year={2010}
}
A wide variety of DNA lesions arise due to environmental agents, normal cellular metabolism, or intrinsic weaknesses in the chemical bonds of DNA. Diverse cellular mechanisms have evolved to maintain genome stability, including mechanisms to repair damaged DNA, to avoid the incorporation of modified nucleotides, and to tolerate lesions (translesion synthesis). Studies of the mechanisms related to DNA metabolism in trypanosomatids have been very limited. Together with recent experimental studies… CONTINUE READING
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