Overview and summary: twenty-five-year followup of high-risk children.

  title={Overview and summary: twenty-five-year followup of high-risk children.},
  author={Allan F. Mirsky and Sol Kugelmass and Loring Ingraham and Eugenia Frenkel and Meena Nathan},
  journal={Schizophrenia bulletin},
  volume={21 2},
We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neurointegrative, and social/personality traits in the preteenage period. The children at risk were also more likely to develop other Axis I disorders, chiefly affective. Moreover, the… CONTINUE READING