Overview and perspectives the transcriptome of Paracoccidioides brasiliensis.

Abstract

Paracoccidioides brasiliensis is a dimorphic and thermo-regulated fungus which is the causative agent of paracoccidioidomycosis, an endemic disease widespread in Latin America that affects 10 million individuals. Pathogenicity is assumed to be a consequence of the dimorphic transition from mycelium to yeast cells during human infection. This review shows the results of the P. brasiliensis transcriptome project which generated 6,022 assembled groups from mycelium and yeast phases. Computer analysis using the tools of bioinformatics revealed several aspects from the transcriptome of this pathogen such as: general and differential metabolism in mycelium and yeast cells; cell cycle, DNA replication, repair and recombination; RNA biogenesis apparatus; translation and protein fate machineries; cell wall; hydrolytic enzymes; proteases; GPI-anchored proteins; molecular chaperones; insights into drug resistance and transporters; oxidative stress response and virulence. The present analysis has provided a more comprehensive view of some specific features considered relevant for the understanding of basic and applied knowledge of P. brasiliensis.

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@article{Andrade2005OverviewAP, title={Overview and perspectives the transcriptome of Paracoccidioides brasiliensis.}, author={Rosangela Vieira de Andrade and Silvana Petrofeza da Silva and Fernando Araripe Torres and Marcio Jos{\'e} Poças-Fonseca and Ildenete Silva-Pereira and Andrea Queiroz Maranh{\~a}o and Elida Geralda Campos and L{\'i}dia Maria Pepe de Moraes and Ros{\'a}lia Santos Amorim Jesu{\'i}no and Maristela Pereira and Celia M. A. Soares and Maria Emilia Telles Walter and Maria Jose{\'a} A Carvalho and Nalvo Almeida and Marcelo Macedo Brigido and Maria Sueli S. Felipe}, journal={Revista iberoamericana de micología}, year={2005}, volume={22 4}, pages={203-12} }