Overview and Treatment of Opioid-Induced Constipation

@article{Mccarberg2013OverviewAT,
  title={Overview and Treatment of Opioid-Induced Constipation},
  author={B. Mccarberg},
  journal={Postgraduate Medicine},
  year={2013},
  volume={125},
  pages={17 - 7}
}
Abstract Opioid analgesics have a central place in the management of both chronic and acute moderate-to-severe pain. However, their potential benefits may be compromised by constipation and other related bowel adverse effects mediated by gastrointestinal μ-opioid receptors. These adverse effects occur in up to 90% of patients treated with opioids, and may be sufficiently debilitating to cause patients to discontinue or modify opioid therapy, thereby compromising effective analgesia. Thorough… Expand
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