Overview and Treatment of Opioid-Induced Constipation

@article{Mccarberg2013OverviewAT,
  title={Overview and Treatment of Opioid-Induced Constipation},
  author={B. Mccarberg},
  journal={Postgraduate Medicine},
  year={2013},
  volume={125},
  pages={17 - 7}
}
  • B. Mccarberg
  • Published 2013
  • Medicine
  • Postgraduate Medicine
  • Abstract Opioid analgesics have a central place in the management of both chronic and acute moderate-to-severe pain. However, their potential benefits may be compromised by constipation and other related bowel adverse effects mediated by gastrointestinal μ-opioid receptors. These adverse effects occur in up to 90% of patients treated with opioids, and may be sufficiently debilitating to cause patients to discontinue or modify opioid therapy, thereby compromising effective analgesia. Thorough… CONTINUE READING

    Topics from this paper.

    Opioid-induced constipation in chronic noncancer pain
    • 8
    Pharmacological Profiles of Oligomerized μ-Opioid Receptors
    • 6
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 52 REFERENCES