Overview: mechanism of translation initiation in eukaryotes.

  title={Overview: mechanism of translation initiation in eukaryotes.},
  author={William C. Merrick},
  volume={44 1-4},
Evidence to date has placed considerable emphasis on protein synthesis initiation as the dominant site of translational control. Two specific aspects are regulated, the binding of the initiator tRNA to the 40S subunits (as a ternary complex with eIF-2 and GTP) and the subsequent binding of mRNA to the complex of the 40S subunit with initiator tRNA. In… CONTINUE READING