Overview: engineering transgenic constructs and mice.

@article{Haruyama2009OverviewET,
  title={Overview: engineering transgenic constructs and mice.},
  author={Naoto Haruyama and Andrew Cho and Ashok Kulkarni},
  journal={Current protocols in cell biology},
  year={2009},
  volume={Chapter 19},
  pages={Unit 19.10}
}
Cell biology research encompasses everything from single cells to whole animals. Recent discoveries concerning particular gene functions can be applied to the whole animal for understanding genotype-phenotype relationships underlying disease mechanisms. For this reason, genetically manipulated mouse models are now considered essential to correctly understand disease processes in whole animals. This unit reviews the basic mouse technologies used to generate conventional transgenic mice, which… CONTINUE READING

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Genetic transformation of mouse embryos by microinjection of purified DNA

  • M. Gossen, H. Bujard
  • Proc . Natl . Acad . Sci . U . S . A .
  • 1992
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