Overview: animal models of osteopenia and osteoporosis.

  title={Overview: animal models of osteopenia and osteoporosis.},
  author={Webster S. S. Jee and Wei Yao},
  journal={Journal of musculoskeletal & neuronal interactions},
  volume={1 3},
Prior to initiating a clinical trial in a post-menopausal osteoporosis study, it is reasonable to recommence the evaluation of treatment in the 9-month-old ovariectomized female rat. A female rat of this age has reached peak bone mass and can be manipulated to simulate clinical findings of post-menopausal osteoporosis. Ample time exists for experimental protocols that either prevent estrogen depletion osteopenia or restore bone loss after estrogen depletion. More time can be saved by… CONTINUE READING