Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data.

@article{Seed2005OverviewUM,
  title={Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data.},
  author={Jennifer Seed and Edward W. Carney and Richard A. Corley and Kevin M. Crofton and John M Desesso and Paul M.D. Foster and Robert J. Kavlock and Gary L. Kimmel and James E Klaunig and M E Bette Meek and R. Julian Preston and William Slikker and Sonia A Tabacova and Gary M Williams and Jeanette Wiltse and R. Thomas Zoeller and Penelope A. Fenner-Crisp and Dorothy E Patton},
  journal={Critical reviews in toxicology},
  year={2005},
  volume={35 8-9},
  pages={664-72}
}
A complete mode of action human relevance analysis--as distinct from mode of action (MOA) analysis alone--depends on robust information on the animal MOA, as well as systematic comparison of the animal data with corresponding information from humans. In November 2003, the International Life Sciences Institute's Risk Science Institute (ILSI RSI) published a 2-year study using animal and human MOA information to generate a four-part Human Relevance Framework (HRF) for systematic and transparent… CONTINUE READING