Overview: Japanese encephalitis

  title={Overview: Japanese encephalitis},
  author={Usha Kant Misra and Jayantee Kalita},
  journal={Progress in Neurobiology},

Japanese Encephalitis Virus: Innate and Adaptive Immunity

JEV transmission occurs through a zoonotic cycle involving mosquitoes as an important intermediate maintenance and replicative vector and pigs and ardeid birds act as amplifying hosts, which does not cause encephalitis in pigs and birds although it is considered as dead end hosts.

Japanese Encephalitis

Japanese encephalitis virus (JEV) is a mosquito–borne agent that can cause encephalococcal disease in equids and humans and reproductive disease in pigs and various vertebrate hosts such as pigs and wild birds and could become endemic in additional regions.

European Monitoring Plans for the Management of Outbreak of JEV(Japanese Encephalitis Virus)

The presence of JEV in Passeriformes of Tuscany constituting the first evidence of this antropo-zoonotic virus in Italy and also in Europe merits further investigation.

Japanese Encephalitis Virus: The Complex Biology of an Emerging Pathogen

Japanese encephalitis virus (JEV) is a flavivirus, which is an emerging threat globally, major‐ ly being southern and Southeast Asia and Australia, and it is estimated that only 0.3% leads to disease causing and results in over 35,000 cases including 10,000 deaths annually worldwide.


The mechanism for JEV pathogenesis is imprecise yet, significant scales of differences are professed in peripheral pathogenicity and neurovirulence between JEV strains, and a large number of vertebrate animal hosts get JEV infection.

Japanese B Encephalitis

There is no FDA-approved antiviral drug available for JEV, and four different kinds of vaccines have been produced to prevent JEV infection.

Japanese Encephalitis Virus: An Emerging Pathogen

In India vaccination against Japanese encephalitis are administered in areas where the disease is hyper-endemic, and DNA based vaccines might aid the purpose of combating against JEV which are presently under clinical trials.

Interventions for the Prevention and Treatment of Japanese Encephalitis

This review gives a comprehensive update on the epidemiology, clinical features, therapeutic trials and approaches for preventing the spread of JE, the most prevalent cause of viral encephalitis in the world.

Re-Examining the Importance of Pigs in the Transmission of Japanese Encephalitis Virus

Findings warrant a re-examination of the role that pigs are playing in the transmission and maintenance of JEV and the possible role of the vector-free JEV transmission route among pigs in viral maintenance.

Perspectives Regarding the Risk of Introduction of the Japanese Encephalitis Virus (JEV) in the United States

This work discusses virus-vector-host interactions and ecological factors important for virus transmission and spread, review research on the risk of JEV introduction to the US considering the implications of risk dismissal, and reflects on future directions, challenges, and implications of a JEV incursion.



[Recent data on the epidemiology of Japanese encephalitis].

  • F. Rodhain
  • Medicine
    Bulletin de l'Academie nationale de medecine
  • 1996
The virologists are looking for other vaccine types, particularly recombinant vaccines relying on obtaining, by genetical manipulation, envelop proteins with protection effect, because of the high cost of the vaccine and the weight of immunization scheme, which make uneasy its integration in the Expanded Vaccination Programme.

Neurovirulence and host factors in flavivirus encephalitis--evidence from clinical epidemiology.

New data based on the complete nucleotide sequence of a virus representing one of the oldest lineages, and phylogenetic analyses of all JEV strains for which genetic data are available, suggest that the distribution is best explained in terms of the virus' origin in the Indonesia-Malaysia region (where all genotypes have been found), and the spread of the more recent genotypes to new geographical areas.

Studies of Japanese encephalitis in China.

  • C. H. Huang
  • Biology, Medicine
    Advances in virus research
  • 1982

Inflammatory markers in the patients of Japanese encephalitis

Results show that TNF-α pathway is involved in JE infection-triggered neuro inflammation, which is associated with severe and irreversible neurological sequelae in survivors.

Association of Japanese encephalitis virus infection with Guillain‐Barré syndrome in endemic areas of South India *

It is concluded that, JEV infection may predispose to Guillain‐Barré syndrome in endemic areas.

Persistence of Japanese encephalitis virus in the human nervous system

Findings suggest that JEV persists in the nervous system of a small proportion of patients, as described in 16/323 laboratory‐confirmed cases of Japanese encephalitis.

Origin and Evolution of Japanese Encephalitis Virus in Southeast Asia

The results suggest that JEV originated from its ancestral virus in the Indonesia-Malaysia region and evolved there into the different genotypes which then spread across Asia, implying that tropical southeast Asia may be an important zone for emerging pathogens.

Japanese encephalitis as an emerging virus: the emergence and spread of Japanese encephalitis virus in Australasia.

The eastward spread of JE from the Oriental to the Australasian zoogeographic region and the threat this poses to the Pacific is the focus of this chapter.

A new genotype of Japanese encephalitis virus from Indonesia.

The existence of three distinct JE genotypes in Asia is demonstrated and a fourth genotype is reported, comprised of five Indonesian isolates that were 7% divergent from the rest of the JE viruses.