Overview, hurdles, and future work in adaptive designs: perspectives from a National Institutes of Health-funded workshop.

@article{Coffey2012OverviewHA,
  title={Overview, hurdles, and future work in adaptive designs: perspectives from a National Institutes of Health-funded workshop.},
  author={Christopher S. Coffey and Bruce Levin and Christina Clark and Cate Timmerman and Janet Wittes and Peter Gilbert and Sara Harris},
  journal={Clinical trials},
  year={2012},
  volume={9 6},
  pages={671-80}
}
BACKGROUND The clinical trials community has a never-ending search for dependable and reliable ways to improve clinical research. This exploration has led to considerable interest in adaptive clinical trial designs, which provide the flexibility to adjust trial characteristics on the basis of data reviewed at interim stages. Statisticians and clinical investigators have proposed or implemented a wide variety of adaptations in clinical trials, but specific approaches have met with differing… CONTINUE READING
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