Oversulfated chondroitin sulfate is not the sole contaminant in heparin

  title={Oversulfated chondroitin sulfate is not the sole contaminant in heparin},
  author={Jing Pan and Yi Qian and Xiaodong Zhou and Andrew Pazandak and Sarah B Frazier and Peter Weiser and Hong Li Lu and Lijuan Zhang},
  journal={Nature Biotechnology},
To the Editor: Contaminated heparin was associated with at least 149 deaths in 2007 and 2008, according to the information published at the US Food and Drug Administration (FDA) website (http://www.fda.gov/ Drugs/DrugSafety/PostmarketDrug SafetyInformationforPatientsandProviders/ ucm112669.htm). Sasisekharan and his colleagues1–3 have analyzed 6 lots of heparin associated with the contamination event and 28 lots of heparin produced by a heparin manufacturer from 2004 to 2007 (ref. 2). Using NMR… CONTINUE READING