Overstretching and force-driven strand separation of double-helix DNA.

  title={Overstretching and force-driven strand separation of double-helix DNA.},
  author={Simona Cocco and Jie Yan and Jean-François L{\'e}ger and Didier Chatenay and John Frederick Daniel Marko},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={70 1 Pt 1},
We analyze whether the "overstretched," or "S" form of double-stranded DNA consists of essentially separated, or essentially interacting, polynucleotide strands. Comparison of force-extension data for S-DNA and single-stranded DNA shows S-DNA to be distinct from both double helix and single-stranded forms. We use a simple thermodynamical model for tension-melted double-stranded DNA, which indicates that the overstretching transition near 65 piconewtons cannot be explained in terms of conversion… CONTINUE READING

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