Overproduction of p53 antigen makes established cells highly tumorigenic

  title={Overproduction of p53 antigen makes established cells highly tumorigenic},
  author={Daniel Eliyahu and Dan Michalovitz and Moshe Oren},
The p53 cellular tumour antigen, long known to be overproduced in a variety of neoplastically transformed cells1,2, was recently shown to be directly involved in transformation. Thus, p53 can complement activated Ha-ras in transforming secondary rat embryo fibroblasts into grossly altered, tumorigenic cells3,4. Moreover, p53 can also be shown to possess immortalizing activity5. Our previous results indicated, however, that the contribution of p53 to the transformation was not synonymous with… CONTINUE READING

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