Overproduction of N-Acetylneuraminic Acid (Sialic Acid) by Sialuria Fibroblasts

@article{Thomas1985OverproductionON,
  title={Overproduction of N-Acetylneuraminic Acid (Sialic Acid) by Sialuria Fibroblasts},
  author={George H. Thomas and Linda W. Reynolds and Carol S. Miller},
  journal={Pediatric Research},
  year={1985},
  volume={19},
  pages={451-455}
}

• George H. Thomas, Linda W. Reynolds, Carol S. Miller
• Published in Pediatric Research 1985
• DOI:10.1203/00006450-198505000-00009

ABSTRAC: Fibroblasts from the original sialuria patientare shown to contain high levels of free sialic acid, i.e., anaverage of 87 versus a normal average of 2 nmol/mg ofprotein. Gas liquid chromatography-mass spectrometryanalysis confirmed that the accumulated material is N-acetylneuraminic acid. Addition of D(+) glucosamine (0-5mM) to the media of these cells increased the intracellularfree sialic acid concentrations from 74 to 137 nmol/mgprotein. In contrast, normal cells treated in an… CONTINUE READING

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