Overproduction of L-cysteine and L-cystine by Escherichia coli strains with a genetically altered serine acetyltransferase.

@article{Nakamori1998OverproductionOL,
  title={Overproduction of L-cysteine and L-cystine by Escherichia coli strains with a genetically altered serine acetyltransferase.},
  author={Shigeru Nakamori and Shouko Kobayashi and Chiho Kobayashi and Hiroshi Takagi},
  journal={Applied and environmental microbiology},
  year={1998},
  volume={64 5},
  pages={1607-11}
}
Organisms that overproduced L-cysteine and L-cystine from glucose were constructed by using Escherichia coli K-12 strains. cysE genes coding for altered serine acetyltransferase, which was genetically desensitized to feedback inhibition by L-cysteine, were constructed by replacing the methionine residue at position 256 of the serine acetyltransferase protein with 19 other amino acid residues or the termination codon to truncate the carboxy terminus from amino acid residues 256 to 273 through… CONTINUE READING

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