Overproduction and purification of RFC-related clamp loaders and PCNA-related clamps from Saccharomyces cerevisiae.

@article{Bylund2006OverproductionAP,
  title={Overproduction and purification of RFC-related clamp loaders and PCNA-related clamps from Saccharomyces cerevisiae.},
  author={G{\"o}ran O. Bylund and Jerzy Majka and Peter M. J. Burgers},
  journal={Methods in enzymology},
  year={2006},
  volume={409},
  pages={1-11}
}
The replication clamp PCNA and its loader RFC (Replication Factor C) are central factors required for processive replication and coordinated DNA repair. Recently, several additional related clamp loaders have been identified. These alternative clamp loaders contain the small Rfc2-5 subunits of RFC, but replace the large Rfc1 subunit by a pathway-specific alternative large subunit, Rad24 for the DNA damage checkpoint, Ctf18 for the establishment of sister chromatid cohesion, and Elg1 for a… CONTINUE READING

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Yeast Rad 17 / Mec 3 / Ddc 1 : A sliding clamp for the DNA damage checkpoint

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  • Proc . Natl . Acad . Sci . USA
  • 2003
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