Overproduced p73alpha activates a minimal promoter through a mechanism independent of its transcriptional activity.

@article{Takagi2001OverproducedPA,
  title={Overproduced p73alpha activates a minimal promoter through a mechanism independent of its transcriptional activity.},
  author={Shuichi Takagi and Yuko Ueda and Makoto Hijikata and Kunitada Shimotohno},
  journal={FEBS letters},
  year={2001},
  volume={509 1},
  pages={47-52}
}
p73, the gene for a protein related to the tumor suppressor p53, encodes several variants which bear distinct carboxy-terminal structures as a result of alternative splicing. We and others showed that these splicing variants have different transcriptional effects on promoters with a p53-binding consensus sequence (p53BCS). Here we show that when transiently overexpressed, p73alpha but not p73beta activated several minimal promoters without the p53BCS, while p73gamma and p73epsilon activated… CONTINUE READING