Overload of the heat-shock protein H11/HspB8 triggers melanoma cell apoptosis through activation of transforming growth factor-β-activated kinase 1

@article{Li2007OverloadOT,
  title={Overload of the heat-shock protein H11/HspB8 triggers melanoma cell apoptosis through activation of transforming growth factor-β-activated kinase 1},
  author={Baiyong Li and Cynthia C. Smith and Jennifer M. Laing and Michael D. Gober and L Liu and Laure Aurelian},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={3521-3531}
}
Molecular therapeutics is a recognized promising approach for melanoma, but relevant target genes remain elusive. We report that overload of the recently cloned H11/HspB8 induces apoptosis in 55% of examined melanoma cultures. Apoptosis was determined by activation of caspases-9 and -3 and terminal deoxynucleotidyltransferase-mediated dUTP nick end labeling (TUNEL), and was not seen in normal melanocytes. It was associated with H11/HspB8 complexation with transforming growth factor-β-activated… CONTINUE READING

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