Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis.


The Spot 14 (S14; Thrsp) gene has been implicated in supporting regulated lipogenesis in mammals. S14 gene expression in liver is controlled by a wide variety of hormones and dietary factors in parallel with the major lipogenic enzyme genes. In addition, mice deleted for the S14 gene display reduced de novo lipogenesis in the lactating mammary gland… (More)
DOI: 10.1210/en.2009-1058