Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing.

@article{Tay2010OverlappingRF,
  title={Overlapping roles for Yen1 and Mus81 in cellular Holliday junction processing.},
  author={Ye Dee Tay and Leonard Wu},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 15},
  pages={
          11427-32
        }
}
Eukaryotic Holliday junction (HJ) resolvases have attracted much attention recently with the identification of at least three distinct proteins that can cleave model HJs in vitro. However, the specific DNA structure(s) that these proteins act upon in the cell is unknown. Here, we describe a system in budding yeast to directly and quantitatively monitor in vivo HJ resolution. We found that Yen1 acts redundantly with Mus81, but not Slx1, to resolve a model HJ in vivo. This functional overlap… CONTINUE READING

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