Overlapping pathways to transplant glomerulopathy: chronic humoral rejection, hepatitis C infection, and thrombotic microangiopathy.

@article{BaidAgrawal2011OverlappingPT,
  title={Overlapping pathways to transplant glomerulopathy: chronic humoral rejection, hepatitis C infection, and thrombotic microangiopathy.},
  author={Seema Baid-Agrawal and Alton Brad Farris and Manuel Querol Pascual and Shamila Mauiyyedi and Mary Lin Farrell and Nina Tolkoff-Rubin and Angela B. Collins and Ulrich A Frei and Robert B. Colvin},
  journal={Kidney international},
  year={2011},
  volume={80 8},
  pages={
          879-85
        }
}
Transplant glomerulopathy (TG) has received much attention in recent years as a symptom of chronic humoral rejection; however, many cases lack C4d deposition and/or circulating donor-specific antibodies (DSAs). To determine the contribution of other causes, we studied 209 consecutive renal allograft indication biopsies for chronic allograft dysfunction, of which 25 met the pathological criteria of TG. Three partially overlapping etiologies accounted for 21 (84%) cases: C4d-positive (48… CONTINUE READING
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