Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.

@article{Vallon2008OverlappingIV,
  title={Overlapping in vitro and in vivo specificities of the organic anion transporters OAT1 and OAT3 for loop and thiazide diuretics.},
  author={Volker Vallon and Timo Rieg and Sun Young Ahn and Wei Wu and Satish A. Eraly and Sanjay K. Nigam},
  journal={American journal of physiology. Renal physiology},
  year={2008},
  volume={294 4},
  pages={F867-73}
}
Organic anion transporter (OAT) genes have been implicated in renal secretion of organic anions, but the individual in vivo contributions of OAT1 (first identified as NKT) and OAT3 remain unclear. Potential substrates include loop diuretics (e.g., furosemide) and thiazide diuretics (e.g., bendroflumethiazide), which reach their tubular sites of action mainly by proximal tubular secretion. Previous experiments in Oat1 knockout (-/-) mice revealed an almost complete loss of renal secretion of the… CONTINUE READING

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Multidrug resistance-associated protein 4 is involved in the F872 RENAL TRANSPORT OF DIURETICS AJP-Renal Physiol

  • M Hasegawa, H Kusuhara, M Adachi, JD Schuetz, K Takeuchi, Y. Sugiyama
  • APRIL
  • 2008
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