Overlapping functions of myosin-I isoforms?

  title={Overlapping functions of myosin-I isoforms? },
  author={E Michael Ostap and Thomas D. Pollard},
  journal={The Journal of Cell Biology},
  pages={221 - 224}
S INCE the discovery of myosin-I (MI) 1 in Acanthamoeba (32), DNA cloning and/or biochemical purification have established the presence of multiple MI isoforms in nearly every eukaryotic cell examined. Despite intensive study, the physiological role of these actin-based, molecular motors has remained a mystery, in large part, because cells express several isoforms of MI with similar biochemical properties. The main questions have been: what are the cellular and molecular functions of MI? Are… CONTINUE READING


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