Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis.

  title={Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis.},
  author={Roel H. Wilting and Eva Yanover and Marinus R. Heideman and Heinz Jacobs and James F Horner and Jaco van der Torre and Ronald A. Depinho and J. G. Dannenberg},
  journal={The EMBO journal},
  volume={29 15},
Histone deacetylases (HDACs) counterbalance acetylation of lysine residues, a protein modification involved in numerous biological processes. Here, Hdac1 and Hdac2 conditional knock-out alleles were used to study the function of class I Hdac1 and Hdac2 in cell cycle progression and haematopoietic differentiation. Combined deletion of Hdac1 and Hdac2, or inactivation of their deacetylase activity in primary or oncogenic-transformed fibroblasts, results in a senescence-like G(1) cell cycle arrest… CONTINUE READING


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