Overlapping cis-acting elements located in the first intron of the gene for type I 3 beta-hydroxysteroid dehydrogenase modulate its transcriptional activity.

@article{Gurin1995OverlappingCE,
  title={Overlapping cis-acting elements located in the first intron of the gene for type I 3 beta-hydroxysteroid dehydrogenase modulate its transcriptional activity.},
  author={Sylvain L. Gu{\'e}rin and Steeve Leclerc and Hugues Verreault and Fernand Labrie and Van Luu-The},
  journal={Molecular endocrinology},
  year={1995},
  volume={9 11},
  pages={
          1583-97
        }
}
High levels of expression for the gene encoding human type I 3 beta-hydroxysteroid dehydrogenase (3 beta-HSDI) have been detected in placenta and skin but not in adrenals, which, however, express high levels of type II 3 beta-HSD. In this study, we addressed the issue of whether the differential pattern of cell-specific expression for type I 3 beta-HSD can be explained by the differential utilization of cis-acting regulatory elements present in the 3 beta-HSDI gene regulatory sequences… CONTINUE READING
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