Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates.

@article{Schiltz1999OverlappingBD,
  title={Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates.},
  author={R. Louis Schiltz and Craig A Mizzen and Alex P Vassilev and Richard G. Cook and C David Allis and Yoshihiro Nakatani},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 3},
  pages={1189-92}
}
A number of transcriptional coactivators possess intrinsic histone acetylase activity, providing a direct link between hyperacetylated chromatin and transcriptional activation. We have determined the core histone residues acetylated in vitro by recombinant p300 and PCAF within mononucleosomes. p300 specifically acetylates all sites of histones H2A and H2B known to be acetylated in bulk chromatin in vivo but preferentially acetylates lysines 14 and 18 of histone H3 and lysines 5 and 8 of histone… CONTINUE READING

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