Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development.

@article{Yang1999OverlappingAI,
  title={Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development.},
  author={Jiong Yang and Bernhard L. Bader and Jordan A. Kreidberg and Mollie Ullman-Cullere and Jane E Trevithick and Richard O Hynes},
  journal={Developmental biology},
  year={1999},
  volume={215 2},
  pages={
          264-77
        }
}
Mouse embryos deficient in fibronectin (FN-null) die at E8.5 with mesodermal defects. Eight integrin heterodimers alpha3beta1, alpha4beta1, alpha5beta1, alpha8beta1, alphavbeta1, alphavbeta3, alphavbeta6, and alphaIIbbeta3 can bind to FN. However, embryos deficient in each of these integrins exhibit less severe defects than do FN-null embryos, raising questions as to which integrin(s) are the key FN receptors for these early FN-dependent processes. alpha5beta1 is believed to be the key receptor… CONTINUE READING

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