Overlapping and Non-overlapping Functions of Condensins I and II in Neural Stem Cell Divisions

@inproceedings{Nishide2014OverlappingAN,
  title={Overlapping and Non-overlapping Functions of Condensins I and II in Neural Stem Cell Divisions},
  author={Kenji Nishide and Tatsuya Hirano},
  booktitle={PLoS genetics},
  year={2014}
}
During development of the cerebral cortex, neural stem cells (NSCs) divide symmetrically to proliferate and asymmetrically to generate neurons. Although faithful segregation of mitotic chromosomes is critical for NSC divisions, its fundamental mechanism remains unclear. A class of evolutionarily conserved protein complexes, known as condensins, is thought to be central to chromosome assembly and segregation among eukaryotes. Here we report the first comprehensive genetic study of mammalian… CONTINUE READING
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