Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture

@article{Laitano2020OverlappingMO,
  title={Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture},
  author={Orlando Laitano and Kevin O Murray and Lisa R Leon},
  journal={Sports Medicine},
  year={2020},
  volume={50},
  pages={1581 - 1592}
}
Exertional heat stroke (EHS) and malignant hyperthermia (MH) are life-threatening conditions, triggered by different environmental stimuli that share several clinical symptoms and pathophysiological features. EHS manifests during physical activity normally, but not always, in hot and humid environments. MH manifests during exposure to haloalkane anesthetics or succinylcholine, which leads to a rapid, unregulated release of calcium (Ca2+) within the skeletal muscles inducing a positive-feedback… Expand

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It is concluded that skeletal muscles should be considered as a key organ system in exertional heat stroke pathophysiology and recovery and is presented and discussed rarely explored roles of skeletal muscles. Expand
Comment on “Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture”
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The authors give an overview of the pathophysiology, epidemiology and treatment of EHS and MH, an intriguing topic with many unresolved questions, and agree with the authors’ statement that E HS and MH are separate entities, but disagree with a number of their statements. Expand
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Response to Comment on “Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture”
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Comments are provided on the concerns raised by van den Bersselaar and colleagues that more work is needed to clarify whether or not there are overlapping mechanisms. Expand
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