Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes

@article{Haywood2006OverlappingBC,
  title={Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes},
  author={Michelle E. K. Haywood and Stephen J. Rose and Stuart D Horswell and Mark Jeffrey Lees and Glenn Fu and Mark J. Walport and Bernard John Morley},
  journal={Genes and Immunity},
  year={2006},
  volume={7},
  pages={250-263}
}
The BXSB mouse strain is an important model of glomerulonephritis observed in systemic lupus erythematosus (SLE). Linkage studies have successfully identified disease-susceptibility intervals; however, extracting the identity of the susceptibility gene(s) in such regions is the crucial next step. Congenic mouse strains present a defined genetic resource that is highly amenable to microarray analysis. We have performed microarray analysis using a series of chromosome 1 BXSB congenic mice with… CONTINUE READING
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