Overlap bias in the case-crossover design, with application to air pollution exposures.

@article{Janes2005OverlapBI,
  title={Overlap bias in the case-crossover design, with application to air pollution exposures.},
  author={Holly E Janes and L. Sheppard and Thomas S. Lumley},
  journal={Statistics in medicine},
  year={2005},
  volume={24 2},
  pages={285-300}
}
The case-crossover design uses cases only, and compares exposures just prior to the event times to exposures at comparable control, or 'referent' times, in order to assess the effect of short-term exposure on the risk of a rare event. It has commonly been used to study the effect of air pollution on the risk of various adverse health events. Proper selection of referents is crucial, especially with air pollution exposures, which are shared, highly seasonal, and often have a long-term time trend… CONTINUE READING

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