Overgrowth syndromes: is dysfunctional PI3-kinase signalling a unifying mechanism?


Studies in drosophila and animal models have shown that the phosphoinositide-3-kinase (PI3-kinase) axis plays a central role in normal development, defining the number and size of cells in tissues. Dysfunction of this pathway leads to growth anomalies and has been established to play a key role in the pathogenesis of Cowden syndrome and tuberous sclerosis… (More)
DOI: 10.1038/sj.ejhg.5201026

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