Overflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and effect of the redox ratio.

@article{Vemuri2006OverflowMI,
  title={Overflow metabolism in Escherichia coli during steady-state growth: transcriptional regulation and effect of the redox ratio.},
  author={Goutham N. Vemuri and Elliot Altman and Dipen Sangurdekar and Arkady B. Khodursky and Mark A. Eiteman},
  journal={Applied and environmental microbiology},
  year={2006},
  volume={72 5},
  pages={3653-61}
}
Overflow metabolism in the form of aerobic acetate excretion by Escherichia coli is an important physiological characteristic of this common industrial microorganism. Although acetate formation occurs under conditions of high glucose consumption, the genetic mechanisms that trigger this phenomenon are not clearly understood. We report on the role of the NADH/NAD ratio (redox ratio) in overflow metabolism. We modulated the redox ratio in E. coli through the expression of Streptococcus pneumoniae… CONTINUE READING

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