Overfeeding Reduces Insulin Sensitivity and Increases Oxidative Stress, without Altering Markers of Mitochondrial Content and Function in Humans

@inproceedings{SamochaBonet2012OverfeedingRI,
  title={Overfeeding Reduces Insulin Sensitivity and Increases Oxidative Stress, without Altering Markers of Mitochondrial Content and Function in Humans},
  author={Dorit Samocha-Bonet and Lesley V Campbell and Trevor A Mori and Kevin D Croft and Jerry R Greenfield and Nigel Turner and Leonie K Heilbronn},
  booktitle={PloS one},
  year={2012}
}
BACKGROUND Mitochondrial dysfunction and increased oxidative stress are associated with obesity and type 2 diabetes. High fat feeding induces insulin resistance and increases skeletal muscle oxidative stress in rodents, but there is controversy as to whether skeletal muscle mitochondrial biogenesis and function is altered. METHODOLOGY AND PRINCIPAL FINDINGS Forty (37 ± 2 y) non-obese (25.6 ± 0.6 kg/m(2)) sedentary men (n = 20) and women (n = 20) were overfed (+1040 ± 100 kcal/day, 46 ± 1% of… CONTINUE READING

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