Overexpression or knockdown of rat tryptophan hyroxylase-2 has opposing effects on anxiety behavior in an estrogen-dependent manner.

@article{Hiroi2011OverexpressionOK,
  title={Overexpression or knockdown of rat tryptophan hyroxylase-2 has opposing effects on anxiety behavior in an estrogen-dependent manner.},
  author={Ryoko Hiroi and Ross A. McDevitt and Paul A. Morcos and Michael S. G. Clark and John F. Neumaier},
  journal={Neuroscience},
  year={2011},
  volume={176},
  pages={120-31}
}
Previous studies showed that chronic estrogen treatment increases tryptophan hydroxylase-2 (TpH2) mRNA in the caudal dorsal raphe nucleus (DRN), and this increase was associated with decreased anxiety. The present study explored the interaction of estrogen and targeted, bidirectional manipulation of TpH2 expression in the caudal DRN by knockdown or viral overexpression, to decrease or increase tryptophan hydroxylase expression respectively, on anxiety behavior. Rats were ovariectomized and… CONTINUE READING

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